Amygdala Lesions Reduce Anxiety-like Behavior in a Human Benzodiazepine-Sensitive Approach–Avoidance Conflict Test

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Amygdala Lesions Reduce Anxiety-like Behavior in a Human Benzodiazepine-Sensitive Approach–Avoidance Conflict Test

BACKGROUND Rodent approach-avoidance conflict tests are common preclinical models of human anxiety disorder. Their translational validity mainly rests on the observation that anxiolytic drugs reduce rodent anxiety-like behavior. Here, we capitalized on a recently developed approach-avoidance conflict computer game to investigate the impact of benzodiazepines and of amygdala lesions on putative ...

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The medial nucleus of the amygdala (am) has been implicated in a variety of social behaviors. The present experiment will test the hypothesis that the effect of am lesions on intermale aggressive behavior is due to interference with social learning processes. Small electrolytic lesions of the am had no significant effect in socially naive male rats. A marked reduction of aggressive behavior was...

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ژورنال

عنوان ژورنال: Biological Psychiatry

سال: 2017

ISSN: 0006-3223

DOI: 10.1016/j.biopsych.2017.01.018